LUDER, E Gene TOPICS IN CLINICAL NUTRITION  1999 SEP ;14(4):22-30


ABSTRACT: Cystic fibrosis (CF) is a common genetic disorder in the Caucasian population. The gen was identified in 1989 on chromosome 7. The encoded gene product, named cystic fibrosis transmembrane conductance regulator (CFTR), corresponds to a cyclic adenosine monophosphate (cAMP)-regulated chloride channel found almost exclusively in the secretory epithelial cells. Although the major mutation that results in a single amino acid deletion (AF508) accounts for 70% of the disease alleles, more than 700 additional mutant alleles of different forms have been detected. A good correlation has been found between CFTR genotype and one of the clinical variables-pancreatic function status. Much has been learned about the feasibility of gene therapy; however, there are substantial challenges ahead before gene therapy for CF can be considered a proven therapeutic option.

Please Note

NOTICE!!! DUE TO THE PANDEMIC , EXPECT A 4-6 WEEK DELAY IN SHIPPING.
We are sorry but we can offer no international Paypal orders. These must be made by Fax. Any inadvertent international Paypal orders placed will be refunded less $20 transaction fee.

P.O. Box 1357
Sparta, NC 28675
Phone: 336-793-6524
Fax: 336-372-1541
Email: sotousa@skybest.com

Shipping Charges

$1.00 - $50.00 = $18.00
$50.01 - $100.00 = $22.00
$100.01 - $150.00 = $27.00
$150.01 - $200.00 = $32.00
Over $200 or more and orders including books ask for shipping charges