Ferrante RJ, Klein AM, Dedeoglu A, Beal MF  J Mol Neurosci  2001 Aug;17(1):89-96


Geriatric Research Education and Clinical Center, Bedford VA Medical Center,MA 01730, USA.

EGb761 is a standardized extract of green Gingko biloba, which exerts protectiveeffects against mitochondrial damage and oxidative stress. We examined whether oral administration of 0.022% or 0.045% EGb761 in the diet could impart neuroprotective effects in a transgenic mouse model (G93A) of amyotrophic lateral sclerosis(ALS). EGb761 significantly improved motor performance and survival, andprotected against a loss of spinal-cord anterior motor horn neurons in male G93A mutant transgenic ALS mice, but not in litter mate female mutant transgene mice. While EGb761 extended survival in litter mate female G93A mice, significance was not reached. EGb761, however, significantly improved weight loss in both male and female transgenic ALS mice. These findings provide evidence for a gender-specific neuroprotective effect of EGb761 in a transgenic model of ALS and suggest that EGb761 may be a potential effective treatment inpatients with ALS.

This entry was posted on Friday, August 17th, 2001 at 12:00 pm and is filed under ALS. You can follow any responses to this entry through the RSS 2.0 feed. Both comments and pings are currently closed.

Please Note

We are sorry but we can offer no international Paypal orders. These must be made by Fax. Any inadvertent international Paypal orders placed will be refunded less $20 transaction fee.

P.O. Box 1357
Sparta, NC 28675
Phone: 336-793-6524
Fax: 336-372-1541
Email: sotousa@skybest.com

Shipping Charges

$1.00 - $50.00 = $18.00
$50.01 - $100.00 = $22.00
$100.01 - $150.00 = $27.00
$150.01 - $200.00 = $32.00
Over $200 or more and orders including books ask for shipping charges