Wang FC, De Pasqua V, Gerard P, Delwaide PJ   Neurology.  2001 Sep 11;57(5):897-9

University Department of Physical Medicine and Rehabilitation, Hopital duSart Tilman, Belgium.

Decrement of the thenar compound muscle action potentials (CMAP), after repetitive nerve stimulation (RNS) of the median nerve at 3 Hz, was evaluated in patients with ALS before riluzole therapy. CMAP size as well as motor unit number and size estimates were evaluated twice before and after 1 year of riluzole therapy. The correlation between decrement and CMAP size reduction per year was highly significant (r = 0.77), but no relationship could be demonstrated between decrement and other variables. The authors thus propose that decrement after RNS may be used as a predictor of further drop in CMAP size.

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