Apostolski, S ;Marinkovic, Z ;Nikolic, A  Journal Of Environmental Pathology, Toxicology  1998;  17(3-4):325-9

ABSTRACT: The activity of glutathione peroxidase (GSH-Px) as well as the activities of other antioxidative enzymes: CuZn superoxide dismutase (CuZnSOD), catalase (CAT), glutathione reductase (GR) in erythrocytes, as well as the activity of plasma glutathione transferase (GST), and the plasma content of vitamins E and C were evaluated in 35 sporadic amyotrophic lateral sclerosis(sALS) patients.  The results revealed significantly decreased activity of both GSH-Px and CuZn SOD in ALS patients exists not only in motoneurons but also in the blood.  The effect of exogenously administered selenium(Se), antioxidants,amino acids, a Ca2+ channel blocker such as nimodipine,and their combination in Alsamin was evaluated by screening parameter levels after 9 weeks of treatment.  Only the use of all components together enhanced the activity of GSH-Px and the amount of vitamin E in sALS patients. Judging by the results of clinical trials, this treatment slowed the courseof the disease.

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