Journal Of Environmental Pathology, Toxicology 1998; 17(3-4):325-9
ABSTRACT: The activity of glutathione peroxidase (GSH-Px) as well as the activities of other antioxidative enzymes: CuZn superoxide dismutase (CuZnSOD), catalase (CAT), glutathione reductase (GR) in erythrocytes, as well as the activity of plasma glutathione transferase (GST), and the plasma content of vitamins E and C were evaluated in 35 sporadic amyotrophic lateral sclerosis(sALS) patients. The results revealed significantly decreased activity of both GSH-Px and CuZn SOD in ALS patients exists not only in motoneurons but also in the blood. The effect of exogenously administered selenium(Se), antioxidants,amino acids, a Ca2+ channel blocker such as nimodipine,and their combination in Alsamin was evaluated by screening parameter levels after 9 weeks of treatment. Only the use of all components together enhanced the activity of GSH-Px and the amount of vitamin E in sALS patients. Judging by the results of clinical trials, this treatment slowed the courseof the disease.